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Lead Exposure & Alzheimer’s Disease: Is There A Link?

A fact sheet for medical professionals

by Dr. Iman Hegazi, MBBS, MD. Forensic Medicine & Toxicology,
Global Lead Advice & Support Service (GLASS), run by The LEAD Group Inc

Alzheimer's disease (AD), or simply Alzheimer's, is the most common form of dementia. This incurable, degenerative, and terminal disease was first described by German psychiatrist and neuropathologist Alois Alzheimer in 1906 and was named after him. (1) Generally it is diagnosed in people over 65 years of age, although the less-prevalent early-onset Alzheimer's can occur much earlier. An estimated 26.6 million people worldwide had Alzheimer's in 2006; this number may quadruple by 2050.  (2, 3)

The term "Alzheimer’s" is rapidly being used by the general public to refer to any elderly person suffering from dementia. Everyone who suffers from Alzheimer's disease has dementia. However, not everyone with dementia has Alzheimer's disease. Dementia may be caused by several other diseases.

History:

Alzheimer’s disease, the chronic decline in intellectual capabilities, was recognized by the ancient Greek physician Hippocrates. At the time "senility" was thought to be simply a normal part of aging (4). Alois Alzheimer, better defined the disease in a speech given in November 1906. Dr. Alzheimer examined the brain, after her death, of a woman who died at the age of 56, after having paranoid delusions, hallucinations, and a loss of memory, and noticed senile plaques and neurofibrillary tangles in the neurons (brain cells) (5). Alzheimer wrote, "On the whole, it is evident that we are dealing with a peculiar, little known disease process." Up until 1970 the diagnosis of Alzheimer’s disease was restricted to patients less than 65 years old(4). Alzheimer’s disease is no longer defined by age with between 50% and 75% of all dementia cases now being diagnosed as Alzheimer’s disease, with the proportion increasing with age (6,7).

Overview of Changes in the Brain:

Alois Alzheimer was able to describe two of the major changes in brain structure caused by Alzheimer’s disease. In addition to the neurofibrillary tangles and neuritic plagues, AD also results in granulovascular degeneration, brain shrinkage, and decreased amounts of neurotransmitters (brain chemicals involved in communication). All of these changes impair the function of brain cells (neurons) and eventually lead to cellular death. Unlike many other cells, the brain is unable to regenerate new neurons. The gradual and progressive death of neurons is mirrored in specific behaviour changes. (4)

Phases of Alzheimer's

Mild dementia

The chief characteristic of mild Alzheimer’s disease is forgetfulness. Not only will the individual misplace items but will start to place them in unusual locations (e.g. keys in the freezer). The decline may be so gradual that it may take family members years to notice since some forgetfulness is a natural part of aging. Loss of a sense of time and direction greatly interferes with the ability to navigate and are important components of a "sense of direction." The characteristic of becoming lost, especially in unfamiliar territory is a common hallmark in mild AD. (4)

Moderate dementia

Once Alzheimer’s disease deteriorates to the moderate stage; profound memory loss that interferes with daily activities characterizes the disorder. The AD patient in the moderate stage is dependent upon others. The sufferer becomes lost even in familiar surroundings and has lost the ability to learn any new material. (4)

Severe dementia

Once the disease progresses to the severe stage the patient suffers from severe impairment of mind (cognitive functions) and body. The subject has reached the point they may no longer recognize their spouse and children. The AD patient no longer has any sense of time or current location. Verbal communication has decreased to the point of phrases, words, or merely syllables are constantly repeated. Eventually, even this simple communication degenerates to a complete inability to speak. The overall loss of coordination and body control means the patient may require help dressing, bathing, grooming, eating, and toileting. (4)

Description: Combination of two diagrams of the brain in one for comparison. Left: A normal brain. Right: The brain of a person with Alzheimer's disease showing extreme shrinkage of the cerebral cortex and hippocampus and enlargement of the ventricles. (8)

The copyright holder of this work grant anyone the right to use this work for any purpose , without any conditions, unless such conditions are required by law. http://en.wikipedia.org/wiki/File:COMPARISONSLICE_HIGH.JPG 

Although Alzheimer’s disease (AD) is a progressive neurodegenerative disorder whose clinical manifestations appear in old age, the initial events that trigger this disease may begin very early in life.

In consequence of the “Barker hypothesis”, which links early life experiences and adult diseases, there is a new concept regarding certain adult diseases that emphasizes the role of environmental factors operating during the preconceptual, fetal, and infantile phases of life. (9)

The sporadic nature of most AD cases strongly argues for an environmental link that may accelerate normal age-related processes in the brain. Due to the widespread occurrence of AD, such environmental agents (risk factors) would have to be widespread and persistent, and chronic human exposure to them very common. Although few environmental agents may fit this description, the heavy metal Pb is widespread and is known to produce permanent behavioral and cognitive perturbations. (10, 11)

Lead (Pb) poses widespread public concern. Humans can be exposed to Pb through paint, glazed earthenware, lead piping, solder in food containers, moonshine whiskey, and automobile battery casings. Occupational exposure to Pb can come from smelters, battery manufacturing, welding, automobile radiator repair, and production of Pb-based paints. Although organic forms of Pb have been removed from gasoline, inorganic Pb still remains the number one environmental hazard facing humans today. (12)

Occupational lead exposure may have long-term effects and dramatically increase the risk of developing Alzheimer's disease in later years, according to research presented during the American Academy of Neurology's 52nd Annual Meeting in San Diego, CA, April 29 -- May 6, 2000. Researchers believe that people who have worked in jobs with high levels of lead exposure are up to 3.4 times more likely to develop Alzheimer's disease.  Dr Koss of the American Academy of Neurology quotes: "Although lead has long been known to be toxic -- and is believed to have affected the brains of some of the rulers of the Roman Empire, thereby causing its downfall -- its long-term damages are difficult to measure, and thus, the extent of its negative effects have been largely overlooked." (13)

The pathogenesis of Alzheimer’s disease: Evidence for an environmental link:

AD pathology is characterized by senile plaques and neurofibrillary tangles (NFTs), combined with massive neuronal loss. The major constituents of senile plaques (or amyloid plaques) are 39–42 residue peptides (Aβ) snipped from a larger protein called the amyloid precursor protein (APP). Current studies indicate that APP is processed by a group of secretases.  Cleavage of APP by β-secretase produces sAPPβ and C99 fragments. C99 is then cleaved by γ-secretase to release Aβ. However, prior processing of APP by α-secretase precludes the formation of the neurotoxic Aβ. Inhibiting α- secretase activity predisposes the processing of APP via the β-secretase pathway, which ultimately leads to neurotoxicity. On the other hand, suppression of β-secretase or γ-secretase activity prevents the formation of the neurotoxic Aβ molecule. (14,15)

Aβ processing and aggregation are thought to be critical events in the etiology of neurodegenerative diseases such as AD. Mutations in APP have been shown to promote AD pathogenesis in familial AD by altering its proteolytic processing, which results in an increased production of Aβ. (16)

Recent studies in rodents have shown that exposure to lead (Pb) during brain development predetermined the expression and regulation of the amyloid precursor protein (APP) and its amyloidogenic β-amyloid (Aβ) product in old age. It is also reported that the expression of AD-related genes [APP, BACE1] as well as their transcriptional regulator (Sp1) were elevated in 23-year-old monkeys exposed to Pb as infants leading to an Alzheimer's disease (AD)-like pathology in the aged monkeys. (17, 18)

Chronic lead (Pb) exposure also affected granule cell morphology in Pb-exposed rats. Dendrites frequently appeared dystrophic, similar to those present in Alzheimer’s disease. Dendrites play an essential role in neuronal signaling and aberrations in dendritic morphology are likely to alter their functional characteristics. (19)

These data suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. The findings implicate an environmental agent (Pb) in the pathogenesis of AD and demonstrate that development is an important period of vulnerability, which could increase future susceptibility to neurodegeneration and AD pathology.

Therapeutic proof of heavy metal implication: 

Clioquinol, a chelating agent used in heavy metal toxicity, is under investigation for the treatment of Alzheimer disease. A pilot phase 2 study with clioquinol showed that the effect of the treatment was significant in the more severely affected group and supports further investigation of this novel treatment. Clioquinol is a chelator that crosses the blood-brain barrier and may diminish the accumulation of amyloid beta in plaques. Clioquinol was shown to produce a significant reversal of amyloid-beta plaque deposition in vitro as well as in vivo in a clinical trial. (20, 21) Another pilot study has shown the efficacy of the chelating agent d-penicillamine in reducing oxidative stress in Alzheimer disease patients. (22)

In conclusion, lead (Pb) is a xenobiotic metal with no known essential function in cellular growth, proliferation, or signalling and there is compelling evidence that exposures to Pb have adverse effects on the nervous system. (23) The sporadic nature of Alzheimer's disease (AD) and a number of studies suggest that AD pathogenesis is influenced by early life exposures and argue for both an environmental trigger and a developmental origin of AD. Recent research presents novel findings that implicate lead (Pb) in the pathogenesis of AD and demonstrate that development is an important period of vulnerability, which could increase future susceptibility to neurodegeneration and AD pathology.

References

  1. Berchtold NC, Cotman CW (1998). "Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s". Neurobiol. Aging 19 (3): 173–89. doi:10.1016/S0197-4580(98)00052-9. PMID 9661992.

  2. Brookmeyer R, Gray S, Kawas C (September 1998). "Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset". Am J Public Health 88 (9): 1337–42. doi:10.2105/AJPH.88.9.1337. PMID 9736873

  3. Brookmeyer R, Johnson E, Ziegler-Graham K, MH Arrighi (July 2007). "Forecasting the global burden of Alzheimer’s disease". Alzheimer's and Dementia 3 (3): 186–91. doi:10.1016/j.jalz.2007.04.381. http://works.bepress.com/cgi/viewcontent.cgi?article=1022&context=rbrookmeyer.

  4. Alzheimer's Disease and Related Disorders SAR Research
    Alzheimer's Overview www.dbs-sar.com/SAR_Research/alzheimer_research.htm

  5. German E Berrios (June 2004) “The history of 'Alzheimer's disease'” The Human Genome23/6/2004 http://genome.wellcome.ac.uk/doc_WTD020951.html

  6. American Psychiatric Association (2006) Practice guidelines for the Treatment Of Psyciatric Disorders Compendium 2006

  7. Alewijn Ott, Monique M B Breteler, Frans van Harskamp, Jules J Claus,  Tischa J M van der Cammen,  Diederick E Grobbee, Albert Hofman (1995) “Prevalence of Alzheimer's disease and vascular dementia: association with education.” The Rotterdam study BMJ 1995;310:970-973 (15 April) www.bmj.com/cgi/content/full/310/6985/970

  8. ADEAR (Alzheimer's Disease Education & referrals center)http://en.wikipedia.org/wiki/File:COMPARISONSLICE_HIGH.JPG 

  9. Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ (1989) Weight in infancy and death from ischaemic heart disease. Lancet 2:577–580. www.thelancet.com/journals/lancet/article/PIIS0140-6736(89)90710-1/abstract

  10.  Yang, Y., Ma, Y., Ni, L., Zhao, S., Li, L., Zhang, J., Fan, M., Liang, C., Cao, J., and Xu, L. (2003) Lead exposure through gestation-only caused long-term learning/memory deficits in young adult offspring. Exp. Neurol. 184, 489–495.

  11. Weisskopf, M. G., Hu, H., Mulkern, R. V., White, R., Aro, A., Oliveira, S., and Wright, R. O. (2004) Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning. Environ. Health Perspect. 112, 620–625.
    www.pubmedcentral.nih.gov/picrender.fcgi?artid=1241931&blobtype=PDF

  12. Goyer, R. A. (1996) Toxic effects of metals, in Casarett and Doull’s Toxicology: The Basic Science of Poisons. Casarett and Doull’s Toxicology: The Basic Science of Poisons (Klaassan C. D., ed) pp. 691–736, McGraw Hill, New York.

  13. Gray Environmental, Inc. Study on the connection between lead exposure and Alzheimer’s disease. May 4, 2000. www.grayenvironmental.com/lead%20exposure%20and%20alzheimers.htm

  14. Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., et al. (1999) Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell. Neurosci. 14, 419–427.  www.ncbi.nlm.nih.gov/pubmed/10656250

  15. Christensen, M. A., Zhou, W., Qing, H., Lehman, A., Philipsen, S., and Song, W. (2004) Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Mol. Cell. Biol. 24, 865–874. www.pubmedcentral.nih.gov/picrender.fcgi?artid=343820&blobtype=PDF

  16. Ross, C. A., and Poirier, M. A. (2004) Protein aggregation and neurodegenerative disease. Nat. Med. 10, S10–S17 www.nature.com/nm/journal/v10/n7s/PDF/nm1066.PDF

  17. Basha, M. R., Wei, W., Bakheet, S. A., Benitez, N., Siddiqi, H. K., Ge, Y., Lahiri, D. K., and Zawia, N. H. (2005) The fetal-basis of amyloidogenesis: exposure to lead and latent over-expression of amyloid precursor protein and β-amyloid in the aging brain. J. Neurosci. 25, 823–829.
    www.jneurosci.org/cgi/reprint/25/4/823

  18. Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, Harry J, Rice DC, Maloney B, Chen D, Lahiri DK, Zawia NH. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. (2008)  J Neurosci.  2;28(1):3-9.  www.jneurosci.org/cgi/reprint/28/1/3
    www.pubmedcentral.nih.gov/picrender.fcgi?artid=2486412&blobtype=PDF
     

  19. Verina, T, Rohde C A., and Guilarte T R. (2007) Environmental Pb2+ exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats. Neuroscience. 30; 145(3): 1037–1047.   www.pubmedcentral.nih.gov/picrender.fcgi?artid=1892316&blobtype=PDF

  20. Ritchie CW, Bush AI, Mackinnon A. Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch Neurol 2003;60(12):1685-91. www.medlink.com/cip.asp?UID=14676042 

  21. Cuajungco MP, Frederickson CJ, Bush AI. Amyloid-beta metal interaction and metal chelation. Subcell Biochem 2005;38:235-54. www.medlink.com/cip.asp?UID=15709482
    www.ncbi.nlm.nih.gov/sites/entrez

  22. Squitti R, Rossini PM, Cassetta E, et al. d-penicillamine reduces serum oxidative stress in Alzheimer's disease patients. Eur J Clin Invest 2002;32:51-9. www.medlink.com/cip.asp?UID=21841062; www.ncbi.nlm.nih.gov/pubmed/11851727

  23. White LD, Cory-Slechta DA, Gilbert ME, Tiffany-Castiglioni E, Zawia NH, Virgolini M, Rossi-George A, Lasley SM, Qian YC, Basha MR. New and evolving concepts in the neurotoxicology of lead. (2007)  Toxicol Appl Pharmacol. 15;225(1):1-27.

PDF version of this file

The LEAD Group Inc. Fact Sheet Index

NSW Lead Reference Centre and NSW Government Publications On this site

  1. About the Global Lead Advice and Support Service (GLASS)

  2. Main Sources of Lead

  3. How Would You Know If You or Your Child Was lead poisoned?

  4. Lead aware housekeeping

  5. Ceiling dust & lead poisoning

  6. Is your yard lead safe?
    你的院子是铅安全的吗

  7. Health Impacts of lead poisoning

  8. Rotary Questionnaire

  9. Lead poisoned Pets and Your Family

  10. Childhood Lead Poisoning Risk Factor Questionnaire

  11. Is Your Child Safe From Lead? - What Can You Do About Lead?

  12. Lead in Drinking Water in Australia

  13. Have We Really Resolved The Lead Issue?

  14. The Importance of the Availability of "Spot Tests" for Lead in Paint

  15. Pregnant or Planning a Pregnancy

  16. Breastfeeding and Lead

  17. Lead in breast milk

  18. Beware The Lead In Lead Lighting

  19. Renting and Lead

  20. What to do if you have too much lead in your tank water

  21. Lead Contamination in Stormwater

  22. Contamination At Shooting Ranges

  23. Banned: Leaded Wick Candles

  24. Lead, Ageing and Death
    铅,衰老和死亡

  25. Metal miniatures: How to minimise the risks of lead poisoning and contamination

  26. 7 Point Plan for the MANAGEMENT OF LEAD by Australian parents and carers

  27. Countries where Leaded Petrol is Possibly Still Sold for Road Use, As at 17th June 2011

  28. Lead Poisoning And The Brain - Cognitive Deficits And Mental Illness

  29. Facts and Firsts of Lead

  30. Lead mining royalties by state and territory

  31. Lead Mining Stewardship - Grey Lead and the Role of The LEAD Group

  32. Preventative Strategies of The LEAD Group

  33. What do Doctors need to do about Lead?

  34. A Naturopath's Experience Of Lead & People With Diagnosed Mental Illness

  35. Case File: Helping Manage Australian Lead in Petrol - How GLASS Works

  36. Glass Web & Service-Users, Experts & Volunteers, by Country; Countries with Leaded Petrol for Road Use & Worst Pollution

  37. Lead in ceiling dust

  38. Lead paint & ceiling dust management - how to do it lead-safely

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    埃斯佩兰斯议会调查后续情况说明书:从这里去哪里??

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  41. Helping a Doctor Help 35,000 Lead-Poisoned People Around the Lead Smelter at La Oroya in Peru
    Ayuda a un doctor que ayuda 35,000 personas envenenadas por plomo alrededor de la fundidora de plomo en la Oroya-Peru
    案例档案:帮助一个医生救助在秘鲁的拉奥罗亚的铅冶炼厂周围的35000铅中毒的人民全球铅咨询和支持的服务机构是怎末工作的

  42. Fact sheet for Australian toy importers and traders

  43. Iron Nutrition & Lead Toxicity
    Informe de Acciones – Hierro y Plomo en la Nutrición
    情况说明书铁的营养和铅的毒性

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  46. Blood lead testing: who to test, when, and how to respond to the result

  47. Dangers of a blood lead level above 2 µg/dL and below 10 µg/dL to both adults and children
    血铅水平高于
    2微克/分升和低于10微克/分升对予成人和儿童的危险。

  48. Lead Exposure & Alzheimer’s Disease: Is There A Link?

  49. In CHINA - Blood lead testing: who to test, when, and how to respond to the result
    在中国血铅测试:谁应该去检查,什么时候,如何对待不同的测试结果

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  52. Ceiling Dust WorkCover Guide Lee Schreiber Final Nov 1999

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  54. The Need for Expert Clinical Assessments in Diagnosis Of Heavy Metal Poisoning

  55. Why you should have your ceiling dust removed before you have insulation installed

  56. Thirty Thought-Starters on Ceiling Void Dust in Homes

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  62. Mencegah kontak dengan timbal di tempat kerja di Indonesia

  63. How to Protect Your Family from Lead in Indonesia

  64. Bagaimana melindungi keluargamu dari timbal di Indonesia

  65. Cigarette Smoking & Lead Toxicity
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  66. Medical Evaluation Questionnaire For Occupational Lead Exposure

  67. Dangers of a blood lead level above 2 µg/dL and below 10 µg/dL to children

  68. Dangers of a blood lead level above 2 µg/dL and below 10 µg/dL to adults

  69. Biosolids used as fertilizer in China and other countries
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  70. What are the lead poisoning risks of a lead pellet, bullet or shot lodged in the body?

  71. Alcohol’s link to higher lead and iron levels

  72. USA Case Definition of Adult (including Occupational) & Child Elevated Blood Lead Levels (EBLL)

  73. Low Level Lead Exposure Harms Children - A Renewed Call for Primary Prevention

  74. Occupational Health & Safety Fact Sheet Dangers of lead for roofers

  75. Let’s Make Leaded Petrol History - Let’s Make Leaded Gasoline History

  76. Lead, Your Health & the Environment. Available in Arabic, Chinese, English, Korean, Macedonian, Spanish, Turkish and Vietnamese 

  77. Lead Safe Housekeeping

  78. Old Lead Paint

  79. Working safely with lead

  80. A Renovator's Guide To The Dangers Of Lead (Brochure 30 pages)

  81. A Guide For Health Care Professionals (Brochure 34 pages)

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  83. Lead Hazard Management In Children's Services (Brochure 15 pages)

  84. A Guide To Dealing With Soil That Might Be Lead-Contaminated

  85. Exposure Assessment: Lead Neurotoxicity - Is the Center for Disease Control's goal to reduce lead below 10 µg/dl blood in all children younger than 72 months by 2010, good enough?

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