Toxicology of Lead part 4
  • At a neuronal level, exposure to lead alters the release of neurotransmitter from presynaptic nerve endings. Spontaneous release is enhanced and evoked release is inhibited. The former may be due to activation of protein kinases in the nerve endings and the latter to blockade of voltage-dependent calcium channels. This disruption of neuronal activity may, in turn, alter the developmental processes of synapse formation and result in a less efficient brain with cognitive deficits.

Bressler JP, Goldstein GW Mechanisms of lead neurotoxicity. Biochem Pharmacol 1991 Feb 15;41(4):479-84

Effect of lead on omega 3 and 6 fats.

More Comprehensive list of Health Effects

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