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QUESTION: Are you interested in having some staff trained to collect oral fluid to measure lead in it? 13/09/09 New South Wales, Australia Anil T. Mangla MS., Ph.D., MPH. FRIPH Chief Lead Epidemiologist, CLPPP Georgia Department of Community Health Division of Public Health GPHA Section Chair Develops Revolutionary Lead Testing Procedure Until now, the only accurate way to test for lead poisoning was through invasive needle or finger sticks. Recently, a safer, less-invasive method with no trauma to the child has been validated by laboratory analysis. The trial found that oral fluid swabs can be used successfully to measure lead levels in children. The clinical trial was designed and correlated by Dr. Anil T. Mangla, Chair of the Maternal and Child Health Section of GPHA and Chief Lead Epidemiologist for the Department of Human Resources, Division of Public Health of Atlanta. Dr. Mangla is also Adjunct Professor at the University of Georgia, and is a Community Assistant Professor at Mercer University, School of Medicine. “The success of this study is a milestone for lead testing on a universal scale,” said Dr. Mangla. “Children living in inner cities are at higher risk of being exposed to lead due to older homes. Also, unlike blood samples which need to be refrigerated, oral fluid swabs do not need refrigerated storage. This is a major benefit when marketed to third world countries.” Another key breakthrough for this test is its “green” factor. There is no medical waste with oral fluid testing which is a major step in eliminating medical waste and the cost associated with it. This test is faster, less invasive and is a far cry from having children endure a painful blood collection. During this study some of the oral fluid samples were collected from children as they slept in their mothers’ arms, encouraging parents to screen their children for lead poisoning. This was the first clinical trial of its kind,
and was completed at Emory University Hospital, Children’s Healthcare of
Atlanta, and at Hughes Spalding Atlanta, Georgia. This trial was administered by
Lynn Gardner MD, Assistant Professor of Pediatrics Emory University and analyzed
by Robyn Hannigan PhD, Co-Inventor of GeoMed Analytical located at the
University of Massachusetts, Boston. All doctors and scientists involved worked
tirelessly No government or corporate funds were used to complete this study. The inventors of this test used personal funds and a strong desire to bring a green, painless, accurate screening tool to the world. More about the clinical trial: Background/Objectives: Current screening practices are complicated by the need to obtain blood from a young child. Oral fluid can be used in vitro to measure lead, but has not been tested in a clinical setting. This study compares oral fluid and blood lead levels in a clinical setting. Conclusion/Implications: Methods: Data analysis used Pearson correlations, scatter plots and linear regression. The mean absolute difference between the sample groups was determined to test the hypothesis that group means are equal (-Ą=0.05). Results: Authors: Gardner L, MD, Geller R, MD, Sun Y, PhD, Mangla A, PhD, Hannigan R, PhD. Abstract Title: Accuracy of Lead Level Measurement Using Oral Fluids |
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ANSWER: Oct 24 2009 Dear Robert, I have been meaning to find the time to call you for weeks but I feel I'd better send this email - it being the weekend and all! There follows a series of communications I've had with Eugene Elwell who has a revolutionary method of determining lead in blood. I promised Eugene that I would talk to you about it to determine your level of interest. Can you please read the following and maybe look at the Boston Channel footage and then get back to me, or to me and Eugene? Thanks for your time - I think this could be a very important development in lead testing. Kind regards Yours Sincerely Elizabeth O'Brien ANSWER: Sep 30 2009 Dear Eugene, thank you very much for forwarding the study Abstract to us. We don't have access to the internet today so I wonder if you would be so kind as to tell me where online the full study is, and if possible, could you email me the full study? I would like to add it to our library. Do you have any idea when this test method, ICP-MS (DRC II, PerkinElmer Sciex), might be available outside of the USA? Or is it already available in any good lab? I look forward to hearing back from you. Kind regards Yours Sincerely Elizabeth O'Brien Update 2013: GPHA Section Chair Develops Revolutionary Lead Testing Procedure Authors: Gardner L, MD, Geller R, MD, Sun Y, PhD, Mangla A, PhD, Hannigan R, PhD. Abstract Title: Accuracy of Lead Level Measurement Using Oral Fluids https://www.gapha.org/gpha-section-chair-develops-revolutionary-lead-testing-procedure/ Posted in News on Jun 12 2009. Copyright 2008-2013 Georgia Public Health Association |
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