Neurofibrillary changes after acute experimental lead poisoning.
Niklowitz WJ. Neurology 1975 Oct;25(10):927-34
Following acute tetraethyl lead intoxication in rabbits classic neurofibrillary tangles develop. As studied by electron microscopy, such tangles develop in hydropic degenerating neurons and consist primarily of bundles of 200 A diameter smooth tubules of enormous length. In two of 16 animals a few twisted tubules (periodicity of 800 A) also could be found. The significance of these lead-induced twisted tubules, so characteristic of Alzheimer's pre-senile dementia in man, is discussed.
|Previous slide||Next slide||Back to first slide||View graphic version|
|Slide 26 of 32|
system lead poisoning |
LEAD Project | egroups | Library
- Fact Sheets | Home
Page | Media Releases
Last Updated 12 March 2014