Toxicology of Lead continued

  • Although the molecular targets for lead are unknown, a vast amount of evidence accumulated over many years has shown that lead disrupts processes that are regulated by calcium.

  • Picomolar concentrations of lead can replace micromolar concentrations of calcium in a protein kinase C enzyme assay. Furthermore, lead activates protein kinase C in intact cells and induces the expression of new genes by a mechanism dependent on protein kinase C. We propose that the learning deficits caused by lead are due to events regulated by protein kinase C that most likely occur at the synapse. Bressler J, Kim KA, Chakraborti T, Goldstein G. Molecular mechanisms of lead neurotoxicity. Neurochem Res 1999 Apr;24(4):595-600

More Comprehensive list of Health Effects

Previous slide Next slide Back to first slide View graphic version
Slide 20 of 32

About Us | bell system lead poisoning | Contact Us | Council LEAD Project | egroups | Library - Fact Sheets | Home Page | Media Releases
Newsletters
| Q & A | Referral lists | Reports | Site Map | Slide Shows - Films | Subscription | Useful LinksSearch this Site

 
 

Run by

The LEAD Group Inc
The Lead Education and Abatement Design Group
Working to eliminate lead poisoning globally and to protect the
environment from lead in all its uses: past, current and new uses
ABN 25 819 463 114
Australians! Take action
today. Is lead harming
you & your kids? Buy low
cost, NATA accredited
laboratory lead test kits
here.
Sample your dust,
soil, water, paint, toys,
jewellery, ceramics
what's new 

Water Lead test Kits

Proceeds from our DIY Home Lead Assessment kit sales go towards the
Keeping Australian Lead Out of Leaded Petrol Initiative.
Visitor Number

Last Updated 12 March 2014
Copyright The LEAD Group Inc. 1991- 2014
PO Box 161 Summer Hill NSW 2130 Australia
Phone: +61 2 9716 0014