Toxicology of Lead contd

  • Although the molecular targets for lead are unknown, a vast amount of evidence accumulated over many years has shown that lead disrupts processes that are regulated by calcium.
  • Picomolar concentrations of lead can replace micromolar concentrations of calcium in a protein kinase C enzyme assay. Furthermore, lead activates protein kinase C in intact cells and induces the expression of new genes by a mechanism dependent on protein kinase C. We propose that the learning deficits caused by lead are due to events regulated by protein kinase C that most likely occur at the synapse. Bressler J, Kim KA, Chakraborti T, Goldstein GMolecular mechanisms of lead neurotoxicity. Neurochem Res 1999 Apr;24(4):595-600
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