Release of lead during osteolysis

  • Pregnancy increases mobilization of lead from maternal skeleton Gulson BL, Jameson CW, Mahaffey KR, Mizon KJ, Korsch MJ, Vimpani G.. J Lab Clin Med 1997a;130:51-62
  • Mobilization of lead from the skeleton during the post-natal period is larger than during pregnancy.
  • Gulson BL, Mahaffey KR, Jameson CW, Mizon KJ, Korsch MJ, Cameron MA, Eisman JA. J Lab Clin Med 1998a;131:324-9
  • Lead is released in menopausal bone loss
  • Lead levels have second peak in middle age- more in men than women (NHANES III).
  • Lead follows calcium into and out of bone.
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