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The
cellular, intracellular and molecular mechanisms
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of lead
neurotoxicity are numerous, as lead impacts
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many
biological activities at different levels of control:
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at the voltage-gated channels and on the
first, second
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and third messenger systems. These effects could be
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related to
lead's ability to interfere
with the regulatory
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action of calcium in
cell functions.
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Finkelstein
Y, Markowitz ME, Rosen JF Low-level lead-induced
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neurotoxicity
in children: an update on central nervous system effects Brain
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Res Brain Res Rev
1998 Jul;27(2):168-76
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