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| Niklowitz
WJ Neurofibrillary changes after acute |
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| experimental
lead poisoning. |
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| Neurology
1975 Oct;25(10):927-34 |
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| v | Following acute tetraethyl lead intoxication in rabbits |
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| classic neurofibrillary tangles develop. As studied by |
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| electron
microscopy, such tangles develop in hydropic |
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| degenerating
neurons and consist primarily of bundles |
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| of 200 A
diameter smooth tubules of enormous length. |
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| In two of 16
animals a few twisted tubules (periodicity |
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| of 800 A)
also could be found. The significance of these |
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| lead-induced
twisted tubules, so characteristic
of |
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| Alzheimer's
pre-senile dementia in man, is discussed. |
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| 26 |