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v |
At a
neuronal level, exposure to lead alters the release of
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neurotransmitter from presynaptic nerve endings. Spontaneous
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release is enhanced and evoked release is inhibited. The former
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may be due
to activation of protein kinases in the nerve endings
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and the
latter to blockade of voltage-dependent calcium channels.
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This
disruption of neuronal activity may, in turn, alter the
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developmental
processes of synapse formation and result in a less
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efficient
brain with cognitive deficits. Bressler
JP, Goldstein GW
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Mechanisms
of lead neurotoxicity. Biochem Pharmacol 1991 Feb
15;41(4):479-84
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?Effect of lead on
omega 3 and 6 fats.
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