Toxicology of Lead 4
v At a neuronal level, exposure to lead alters the release of
neurotransmitter from presynaptic nerve endings. Spontaneous
release is enhanced and evoked release is inhibited. The former
may be due to activation of protein kinases in the nerve endings
and the latter to blockade of voltage-dependent calcium channels.
This disruption of neuronal activity may, in turn, alter the
developmental processes of synapse formation and result in a less
efficient brain with cognitive deficits. Bressler JP, Goldstein GW
Mechanisms of lead neurotoxicity. Biochem Pharmacol 1991 Feb 15;41(4):479-84
v ?Effect of lead on omega 3 and 6 fats.
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