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Lead
disrupts the main structural components of the
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blood-brain
barrier by primary
injury to astrocytes
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with a
secondary damage to the endothelial
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microvasculature.
Within the brain, lead-induced
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damage
occurs preferentially in the prefrontal
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cerebral cortex, hippocampus and cerebellum. Some
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characteristic
clinical features of lead poisoning may
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be
attributed to this specific anatomical pattern.
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