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Although the
molecular targets for lead are unknown, a vast
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amount of
evidence accumulated over many years has shown that
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lead
disrupts processes that are regulated by calcium.
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| v |
Picomolar concentrations of lead can replace micromolar
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concentrations of calcium in a protein
kinase C enzyme assay.
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Furthermore,
lead activates protein kinase C in intact cells and
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induces the
expression of new genes by a mechanism dependent
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on protein
kinase C. We propose that the learning deficits caused
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by lead are
due to events regulated by protein kinase C that most
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likely occur at the
synapse.
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Bressler J, Kim KA, Chakraborti T,
Goldstein GMolecular mechanisms of lead
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neurotoxicity.
Neurochem Res 1999 Apr;24(4):595-600
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