vAt a neuronal level, exposure to lead alters the release of neurotransmitter from presynaptic nerve
endings. Spontaneous release
is enhanced and evoked release is inhibited. The former may be due
to activation of protein kinases in the nerve endings and the latter to blockade of voltage-dependent calcium
channels. This disruption of
neuronal activity may, in turn, alter the developmental processes of synapse formation and result
in a less efficient brain with
cognitive deficits. Bressler JP,
Goldstein GW Mechanisms of lead neurotoxicity. Biochem Pharmacol 1991 Feb 15;41(4):479-84
v?Effect of lead on omega 3 and 6 fats.